Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.31 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3216202 | 0.92 | PTPN1 (0.56) | PTPN1PTPN2ERCC1ERCC4 | |
| SCHEMBL4556367 | 0.88 | PTPN1 (0.53) | PTPN1PTPN2ERCC1ERCC4PTGER4 | |
| SCHEMBL4785563 | 0.85 | PTPN1 (0.37) | PTPN1KMT2A | |
| SCHEMBL2938403 | 0.85 | PTPN1 (0.60) | PTPN1PTPN2 | |
| SCHEMBL3919898 | 0.85 | PTPN1 (0.43) | PTPN1PTPN2POLBKMT2ALMNA | |
| SCHEMBL4785568 | 0.80 | PTPN1 (0.45) | PTPN1PTPN2KMT2A | |
| SCHEMBL3219890 | 0.79 | PTPN1 (0.58) | PTPN1PTPN2POLBLMNA | |
| SCHEMBL3917680 | 0.77 | PTPN1 (0.45) | PTPN1PTPN2KMT2A | |
| SCHEMBL3224679 | 0.76 | PTPN1 (0.62) | PTPN1PTPN2 | |
| SCHEMBL1911435 | 0.76 | PTPN1 (0.50) | PTPN1PTPN2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089026-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | Novartis AG (CH) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008070552-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | NOVARTIS AG (CH) | 2008-06-12 | — | — | WO | disclosed |