Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3219632 | 0.90 | PTPN1 (0.53) | PTPN1PTPN2NPC1RAB9AKMT2A | |
| SCHEMBL4556367 | 0.90 | PTPN1 (0.53) | PTPN1PTPN2MCL1 | |
| SCHEMBL3216202 | 0.87 | PTPN1 (0.56) | PTPN1PTPN2MCL1 | |
| SCHEMBL4785563 | 0.85 | PTPN1 (0.37) | PTPN1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL3219890 | 0.82 | PTPN1 (0.58) | PTPN1PTPN2MAPTHPGDTSHR | |
| SCHEMBL4556368 | 0.80 | PTPN1 (0.51) | PTPN1PTPN2KMT2A | |
| SCHEMBL3919898 | 0.76 | PTPN1 (0.43) | PTPN1PTPN2HTTNPC1RAB9A | |
| SCHEMBL2938403 | 0.75 | PTPN1 (0.60) | PTPN1PTPN2ALDH1A1 | |
| SCHEMBL27737670 | 0.74 | PTPN1 (0.35) | PTPN1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL649557 | 0.72 | PTPN1 (0.64) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008067527-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | NOVARTIS AG (CH) | 2008-06-05 | — | — | WO | disclosed |