Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2881452 | 0.96 | MAPT (0.52) | MAPTPOLBALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3031375 | 0.77 | EPAS1 (0.40) | MAPTPOLBALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2878659 | 0.77 | ALDH1A1 (0.47) | MAPTPOLBALDH1A1GAASMN1; SMN2 | |
| SCHEMBL9818964 | 0.77 | MAPT (0.67) | MAPTPOLBALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2511485 | 0.76 | EPAS1 (0.34) | MAPTPOLBALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2326248 | 0.75 | MAPT (0.64) | MAPTPOLBALDH1A1GAASMN1; SMN2 | |
| SCHEMBL58157 | 0.74 | TDP1 (0.65) | MAPTPOLBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL28282595 | 0.74 | TDP1 (0.65) | MAPTPOLBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL29460277 | 0.74 | TDP1 (0.65) | MAPTPOLBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL3028132 | 0.74 | EPAS1 (0.38) | MAPTPOLBALDH1A1SMN1; SMN2HSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121638-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008076225-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK & CO., INC. (US) | 2008-06-26 | — | — | WO | disclosed |