Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 11/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4556897 | 0.71 | MAPT (0.45) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL4564379 | 0.71 | SMN1; SMN2 (0.48) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL9149975 | 0.70 | HIF1A (0.49) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL21060952 | 0.70 | HIF1A (0.49) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL4169300 | 0.68 | MAPT (0.54) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL11385980 | 0.68 | MAPT (0.40) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL22734765 | 0.68 | HIF1A (0.53) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL490816 | 0.66 | HIF1A (0.62) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL891143 | 0.65 | HIF1A (0.66) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL17156498 | 0.65 | HIF1A (0.60) | MAPTHTTHIF1AEPAS1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009015180-A2 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |