Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | IRS1 | P35568 | 1/20 | 0.39 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4556897 | 0.93 | MAPT (0.45) | SMN1; SMN2MAPTHTTHIF1AEPAS1 | |
| SCHEMBL11884889 | 0.80 | ALDH1A1 (0.56) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL9339119 | 0.80 | KMT2A (0.50) | SMN1; SMN2HSD17B10ALDH1A1NR4A1 | |
| SCHEMBL4169300 | 0.79 | MAPT (0.54) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL9149975 | 0.77 | HIF1A (0.49) | SMN1; SMN2MAPTHTTHIF1AEPAS1 | |
| SCHEMBL21060952 | 0.77 | HIF1A (0.49) | SMN1; SMN2MAPTHTTHIF1AEPAS1 | |
| SCHEMBL17156498 | 0.75 | HIF1A (0.60) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL891349 | 0.75 | HIF1A (0.66) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL890821 | 0.75 | HIF1A (0.66) | MAPTHTTHIF1AEPAS1GPR84 | |
| SCHEMBL7243687 | 0.74 | ALDH1A1 (0.62) | MAPTHIF1APPARAPPARGHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009015180-A2 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |