Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 20/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 8/20 | 0.38 |
| ▸ | CASP6 | P55212 | 6/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CASP9 | P55211 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555751 | 1.00 | CASP3 (0.39) | CASP3CASP8CASP6CASP1CASP9 | |
| SCHEMBL4556594 | 0.92 | CASP3 (0.47) | CASP3CASP8CASP6CASP1CASP9 | |
| SCHEMBL4446027 | 0.92 | CASP3 (0.47) | CASP3CASP8CASP6CASP1CASP9 | |
| SCHEMBL4249886 | 0.88 | CASP3 (0.46) | CASP3CASP8CASP6 | |
| SCHEMBL4249880 | 0.88 | CASP3 (0.46) | CASP3CASP8CASP6 | |
| SCHEMBL4251576 | 0.88 | CASP3 (0.46) | CASP3CASP8CASP6 | |
| SCHEMBL15085572 | 0.87 | CASP3 (0.40) | CASP3CASP8CASP6CASP1CASP9 | |
| SCHEMBL4451523 | 0.87 | CASP3 (0.40) | CASP3CASP8CASP6CASP1CASP9 | |
| SCHEMBL4556696 | 0.85 | CASP3 (0.38) | CASP3CASP8CASP6CASP1CASP9 | |
| SCHEMBL4451536 | 0.85 | CASP3 (0.38) | CASP3CASP8CASP6CASP1CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481537-B2 | Caspase inhibitors based of pyridazinone scaffold | LG LIFE SCIENCES LTD. (KR) | 2013-07-09 | — | — | US | disclosed |
| EP-2046757-A1 | CASPASE INHIBITORS BASED ON PYRIDAZINONE SCAFFOLD | LG Life Sciences Ltd. (KR) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008016239-A1 | CASPASE INHIBITORS BASED ON PYRIDAZINONE SCAFFOLD | LG LIFE SCIENCES LTD. (KR) | 2008-02-07 | — | — | WO | disclosed |