Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 6/20 | 0.38 |
| ▸ | CA2 | P00918 | 6/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930353 | 0.96 | PTPN1 (0.45) | PTPN1CA1CA2SIGMAR1NAMPT | |
| SCHEMBL4312575 | 0.95 | PTPN1 (0.45) | PTPN1CA1CA2SIGMAR1NAMPT | |
| Potassium SCHEMBL4131736 | 0.95 | PTPN1 (0.45) | PTPN1CA1CA2SIGMAR1NAMPT | |
| SCHEMBL2931809 | 0.90 | PTPN1 (0.47) | PTPN1CA1CA2NAMPTDDB1 | |
| SCHEMBL2928485 | 0.84 | PTPN1 (0.52) | PTPN1DRD2 | |
| SCHEMBL3224621 | 0.82 | PTPN1 (0.47) | PTPN1LIPG | |
| SCHEMBL3221602 | 0.81 | PTPN1 (0.45) | PTPN1SIGMAR1 | |
| SCHEMBL3920782 | 0.81 | MTNR1A (0.45) | PTPN1SIGMAR1NAMPTDDB1CRBN | |
| SCHEMBL3214468 | 0.80 | PTPN1 (0.45) | PTPN1HDAC2HDAC8HDAC6 | |
| SCHEMBL12056194 | 0.80 | PTPN1 (0.47) | PTPN1CA1CA2NAMPTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089026-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | Novartis AG (CH) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008070552-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | NOVARTIS AG (CH) | 2008-06-12 | — | — | WO | disclosed |