Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 9/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 8/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 7/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.36 |
| ▸ | CDK2 | P24941 | 6/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.36 |
| ▸ | CDK9 | P50750 | 4/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460987 | 0.82 | AKT1 (0.31) | AKT1AKT2 | |
| SCHEMBL477062 | 0.78 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2TNFDYRK1A | |
| SCHEMBL18817029 | 0.78 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2TNFDYRK1A | |
| SCHEMBL3115930 | 0.73 | NTRK1 (0.50) | KDM4EALDH1A1SMN1; SMN2TNFDYRK1A | |
| SCHEMBL3108672 | 0.73 | AKT1 (0.41) | KDM4EALDH1A1SMN1; SMN2TNFDYRK1A | |
| SCHEMBL1745899 | 0.71 | DYRK1A (0.41) | KDM4EALDH1A1SMN1; SMN2TNFDYRK1A | |
| SCHEMBL4052890 | 0.70 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2TNFDYRK1A | |
| SCHEMBL1394183 | 0.70 | AKT1 (0.40) | KDM4EALDH1A1SMN1; SMN2TNFDYRK1A | |
| SCHEMBL3721378 | 0.69 | ALDH1A1 (0.37) | KDM4EALDH1A1SMN1; SMN2TNFDYRK1A | |
| SCHEMBL3728019 | 0.69 | MKNK1 (0.39) | KDM4EALDH1A1SMN1; SMN2TNFDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2825540-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2015-01-21 | — | — | EP | disclosed |
| WO-2013135612-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-09-19 | — | — | WO | disclosed |
| EP-2614063-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |