Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 5/20 | 0.49 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL443807 | 0.97 | STS (0.52) | STSKDM2BHSD11B1TSHRABL1 | |
| SCHEMBL5940516 | 0.90 | STS (0.57) | STSHSD11B1TSHRABL1RIN1 | |
| SCHEMBL15260632 | 0.87 | STS (0.49) | STSHSD11B1ABL1RIN1KMT2A | |
| SCHEMBL15260631 | 0.87 | STS (0.49) | STSHSD11B1ABL1RIN1KMT2A | |
| SCHEMBL2326008 | 0.81 | ALDH1A1 (0.49) | KDM2BABL1RIN1KMT2AUSP30 | |
| SCHEMBL2326004 | 0.81 | ALDH1A1 (0.49) | KDM2BABL1RIN1KMT2AUSP30 | |
| SCHEMBL30066884 | 0.80 | STS (0.54) | STSHSD11B1ABL1RIN1KMT2A | |
| SCHEMBL29189288 | 0.80 | STS (0.54) | STSHSD11B1ABL1RIN1KMT2A | |
| SCHEMBL1991537 | 0.79 | KMT2A (0.52) | STSHSD11B1ABL1RIN1KMT2A | |
| SCHEMBL1991541 | 0.79 | KMT2A (0.52) | STSHSD11B1ABL1RIN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102157-A1 | HETEROARYL PYRROLIDINYL AND PIPERIDINYL KETONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008074703-A1 | HETEROARYL PYRROLIDINYL AND PIPERIDINYL KETONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-26 | — | — | WO | disclosed |