Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP12 | P39900 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP14 | P50281 | 2/20 | 0.41 |
| ▸ | MMP16 | P51512 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28580702 | 0.86 | PTGS2 (0.55) | PTGS2PTGS1ELANEKMT2ACXCL8 | |
| SCHEMBL2729150 | 0.84 | CYP1A2 (0.48) | KMT2AIRAK4TSHRLMNA | |
| SCHEMBL6515789 | 0.82 | PTGS2 (0.49) | PTGS2PTGS1ELANEKMT2AIRAK4 | |
| SCHEMBL8473051 | 0.82 | PTGS2 (0.64) | PTGS2PTGS1KMT2AMMP2MMP9 | |
| SCHEMBL7885098 | 0.82 | PTGS2 (0.64) | PTGS2PTGS1KMT2AMMP2MMP9 | |
| SCHEMBL362211 | 0.82 | PTGS2 (0.64) | PTGS2PTGS1KMT2AMMP2MMP9 | |
| SCHEMBL10456136 | 0.79 | TSHR (0.39) | KMT2ACXCL8KDM4EALDH1A1HPGD | |
| SCHEMBL10456134 | 0.79 | TSHR (0.39) | KMT2ACXCL8KDM4EALDH1A1HPGD | |
| SCHEMBL6838437 | 0.78 | TSHR (0.50) | KMT2AIRAK4KDM4EALDH1A1TSHR | |
| SCHEMBL1345669 | 0.77 | PTGS1 (0.54) | PTGS2PTGS1KMT2ACXCL8MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635822-A4 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | ELAN PHARM INC (US) | 2009-06-24 | — | — | EP | disclosed |
| EP-1635822-A2 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | Elan Pharmaceuticals, Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005000246-A2 | METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS | ELAN PHARMACEUTICALS, INC. (US) | 2005-01-06 | — | — | WO | disclosed |