Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.70 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.70 |
| ▸ | CDK1 | P06493 | 1/20 | 0.70 |
| ▸ | GSK3B | P49841 | 1/20 | 0.70 |
| ▸ | CDK7 | P50613 | 1/20 | 0.70 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.70 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.70 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.70 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.70 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.70 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.70 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.70 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.70 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.70 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.70 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL477994 | 0.87 | DYRK3 (0.64) | CDK2DYRK3CDK1GSK3BCDK7 | |
| SCHEMBL4064506 | 0.85 | CDK1 (0.65) | CDK2DYRK3CDK1GSK3BCDK7 | |
| SCHEMBL4069900 | 0.85 | CDK1 (0.74) | CDK2DYRK3CDK1GSK3BCDK7 | |
| SCHEMBL10079716 | 0.85 | CDK7 (0.74) | CDK2DYRK3CDK1GSK3BCDK7 | |
| SCHEMBL477976 | 0.84 | CDK2 (0.59) | CDK2DYRK3CDK1GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL4057891 | 0.84 | CDK1 (0.64) | CDK2DYRK3CDK1GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL4066580 | 0.84 | CDK1 (0.72) | CDK2DYRK3CDK1GSK3BCDK7 | |
| SCHEMBL4061413 | 0.84 | CDK1 (0.69) | CDK2DYRK3CDK1GSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL4064202 | 0.83 | CDK1 (0.68) | CDK2DYRK3CDK1GSK3BCDK7 | |
| SCHEMBL396747 | 0.83 | DYRK3 (0.50) | CDK2DYRK3CDK1GSK3BCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017455-A1 | A NEW COMBINATION OF (A) AN ALPHA-4-BETA-2 -NEURONAL NICOTINIC AGONIST AND (B) A GSK3 INHIBITOR | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |