Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 4/20 | 0.65 |
| ▸ | GSK3B | P49841 | 3/20 | 0.65 |
| ▸ | CDK2 | P24941 | 2/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.65 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.65 |
| ▸ | CDK7 | P50613 | 1/20 | 0.65 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.65 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.65 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.65 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.65 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.65 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.65 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.65 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.65 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.65 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4057891 | 0.99 | CDK1 (0.64) | CDK1GSK3BCDK2CDK5DYRK3 | |
| SCHEMBL4069900 | 0.92 | CDK1 (0.74) | CDK1GSK3BCDK2CDK5DYRK3 | |
| Hydrochloric Acid SCHEMBL4066580 | 0.91 | CDK1 (0.72) | CDK1GSK3BCDK2CDK5DYRK3 | |
| SCHEMBL4061413 | 0.88 | CDK1 (0.69) | CDK1GSK3BCDK2CDK5DYRK3 | |
| Hydrochloric Acid SCHEMBL4064202 | 0.88 | CDK1 (0.68) | CDK1GSK3BCDK2CDK5DYRK3 | |
| SCHEMBL4025806 | 0.85 | CDK7 (0.85) | CDK1GSK3BCDK2CDK5DYRK3 | |
| SCHEMBL4558231 | 0.85 | CDK2 (0.70) | CDK1GSK3BCDK2CDK5DYRK3 | |
| Hydrochloric Acid SCHEMBL4058368 | 0.84 | CDK7 (0.84) | CDK1GSK3BCDK2CDK5DYRK3 | |
| SCHEMBL477994 | 0.83 | DYRK3 (0.64) | CDK1GSK3BCDK2CDK5DYRK3 | |
| SCHEMBL10079716 | 0.81 | CDK7 (0.74) | CDK1GSK3BCDK2CDK5DYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-B9 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | claimed |
| US-20090149460-A1 | New Compounds | BERG STEFAN | 2009-06-11 | — | — | US | claimed |
| EP-1492785-B1 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-03 | — | — | EP | claimed |
| US-7399780-B2 | 3-Heterocyclyl-indole inhibitors of glycogen synthase kinase-3 | ASTRAZENECA AB (SE) | 2008-07-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149460-A1 | New Compounds | SDHA, CYP11B2, SERPINB1 | CDK1 263/4885GSK3B 1261/4885CDK2 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.