SCHEMBL4558311 — predicted protein targets

Predicted protein targets (top 16)

	gene	UniProt	supporting neighbours	confidence
▸	HRH4	Q9H3N8	7/20	0.53

▸	SMYD3	Q9H7B4	6/20	0.47

▸	NSD2	O96028	1/20	0.44

▸	SETD2	Q9BYW2	1/20	0.44

▸	SYK	P43405	2/20	0.43

▸	DRD4	P21917	1/20	0.40

▸	PBK	Q96KB5	1/20	0.40

▸	PYGL	P06737	1/20	0.39

▸	PYGM	P11217	1/20	0.39

▸	NPC1	O15118	1/20	0.38

▸	POLB	P06746	1/20	0.38

▸	MAPT	P10636	1/20	0.38

▸	RAB9A	P51151	1/20	0.38

▸	L3MBTL1	Q9Y468	1/20	0.38

▸	BRD4	O60885	1/20	0.38

▸	ATAD2	Q6PL18	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4558593	0.93	HRH4 (0.51)	HRH4SMYD3NSD2SETD2SYK
SCHEMBL3607953	0.82	SMYD3 (0.69)	HRH4SMYD3NSD2SETD2BRD4
SCHEMBL3606352	0.82	SMYD3 (0.69)	HRH4SMYD3NSD2SETD2BRD4
SCHEMBL3606357	0.82	SMYD3 (0.69)	HRH4SMYD3NSD2SETD2BRD4
SCHEMBL25532031	0.81	SMYD3 (0.45)	SMYD3NSD2SETD2SYKPBK
SCHEMBL3604188	0.81	SMYD3 (0.47)	HRH4SMYD3NSD2SETD2SYK
SCHEMBL3604185	0.81	SMYD3 (0.47)	HRH4SMYD3NSD2SETD2SYK
SCHEMBL3611294	0.81	SMYD3 (0.47)	SMYD3NSD2SETD2SYKDRD4
SCHEMBL3611297	0.81	SMYD3 (0.47)	SMYD3NSD2SETD2SYKDRD4
SCHEMBL3616197	0.81	SMYD3 (0.47)	SMYD3NSD2SETD2SYKDRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2009158375-A1	AZA-CYLIC INDOLE- 2 -CARBOXAMIDES AND METHODS OF USE THEREOF	ABBOTT LABORATORIES (US)	2009-12-30	—	—	WO	claimed