Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 16/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1219523 | 0.86 | HSP90AB1 (0.62) | HSP90AA1HSP90AB1OPRM1HTTKMT2A | |
| SCHEMBL1221266 | 0.81 | HSP90AB1 (0.64) | HSP90AA1HSP90AB1OPRM1 | |
| SCHEMBL4558724 | 0.78 | OPRM1 (0.73) | HSP90AA1HSP90AB1OPRM1HTTKMT2A | |
| SCHEMBL1220823 | 0.75 | HSP90AB1 (0.63) | HSP90AA1HSP90AB1OPRM1OPRK1OPRD1 | |
| SCHEMBL1220635 | 0.75 | HSP90AB1 (0.62) | HSP90AA1HSP90AB1OPRM1 | |
| SCHEMBL1220570 | 0.74 | HSP90AB1 (0.62) | HSP90AA1HSP90AB1OPRM1 | |
| SCHEMBL4592401 | 0.73 | HSP90AB1 (0.61) | HSP90AA1HSP90AB1OPRM1 | |
| SCHEMBL1220886 | 0.73 | HSP90AB1 (0.61) | HSP90AA1HSP90AB1OPRM1 | |
| SCHEMBL15613351 | 0.72 | HSP90AB1 (0.67) | HSP90AA1HSP90AB1OPRM1OPRK1OPRD1 | |
| SCHEMBL1220755 | 0.72 | HSP90AB1 (0.63) | HSP90AA1HSP90AB1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4377942-B2 | — | — | 2009-12-02 | — | — | JP | claimed |
| JP-2008531599-A | — | — | 2008-08-14 | — | — | JP | claimed |
| EP-1856057-A1 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | Serenex, Inc. (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006091963-A1 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX, INC. (US) | 2006-08-31 | — | — | WO | claimed |