Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.71 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | MATK | P42679 | 1/20 | 0.50 |
| ▸ | FRK | P42685 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | GCGR | P47871 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4458847 | 0.89 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL6581827 | 0.89 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL4474894 | 0.89 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL9209796 | 0.88 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| Hydrochloric Acid SCHEMBL9203423 | 0.86 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL9216064 | 0.85 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL4476561 | 0.83 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4464495 | 0.83 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL9665340 | 0.82 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL4467677 | 0.81 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582660-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | C-A-I-R BIOSCIENCES GMBH (DE) | 2009-09-01 | — | — | US | disclosed |
| EP-1539741-A1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS | MERCKLE GMBH (DE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018458-A1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS | MERCKLE-GMBH (DE) | 2004-03-04 | — | — | WO | disclosed |