Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.77 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.58 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PTGES | O14684 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9203423 | 0.99 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL9216064 | 0.91 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL9665340 | 0.91 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL4558719 | 0.88 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL4467677 | 0.87 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4464495 | 0.85 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL4476561 | 0.85 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9209341 | 0.84 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL5448383 | 0.83 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL9214708 | 0.82 | KDM4E (0.62) | MAPK14KDM4EALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510036-B1 | 2-SUBSTITUTED 4,5-DIPHENYL-IMIDAZOLES | RHONE POULENC RORER SA (FR) | 1995-04-19 | — | — | EP | disclosed |
| EP-0510036-A1 | 2-SUBSTITUTED 4,5-DIPHENYL-IMIDAZOLES. | RHONE POULENC RORER SA (FR) | 1992-10-28 | — | — | EP | disclosed |
| WO-1991010662-A1 | 2-SUBSTITUTED 4,5-DIPHENYL-IMIDAZOLES | RHONE-POULENC RORER S.A. (FR) | 1991-07-25 | — | — | WO | disclosed |