Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 12/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL456990 | 0.86 | TNF (0.46) | SCN5AERN1TNFALDH1A1SMN1; SMN2 | |
| SCHEMBL470155 | 0.86 | TNF (0.46) | SCN5AERN1TNFALDH1A1SMN1; SMN2 | |
| SCHEMBL457022 | 0.86 | TNF (0.46) | SCN5AERN1TNFALDH1A1SMN1; SMN2 | |
| SCHEMBL456397 | 0.85 | TNF (0.43) | SCN5AERN1TNFALDH1A1SMN1; SMN2 | |
| SCHEMBL457647 | 0.82 | ERN1 (0.43) | ERN1 | |
| SCHEMBL463409 | 0.73 | TTK (0.62) | — | |
| SCHEMBL104696 | 0.70 | TTK (0.36) | ERN1 | |
| SCHEMBL470022 | 0.70 | PI4KB (0.41) | ERN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL455120 | 0.69 | TTK (0.36) | ERN1 | |
| SCHEMBL458996 | 0.69 | ERN1 (0.36) | ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255100-B2 | Substituted imidazopyridazines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-02-09 | — | — | US | disclosed |
| EP-2614063-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |