Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3547377 | 0.84 | CHRNB2 (0.42) | DPP4DPP8DPP9CHRNB2CHRNA4 | |
| SCHEMBL589711 | 0.84 | CHRNB2 (0.42) | DPP4DPP8DPP9CHRNB2CHRNA4 | |
| SCHEMBL3534892 | 0.84 | CHRNB2 (0.42) | DPP4DPP8DPP9CHRNB2CHRNA4 | |
| SCHEMBL788022 | 0.84 | CHRNB2 (0.42) | DPP4DPP8DPP9CHRNB2CHRNA4 | |
| SCHEMBL1303905 | 0.84 | CHRNB2 (0.42) | DPP4DPP8DPP9CHRNB2CHRNA4 | |
| SCHEMBL1439294 | 0.84 | CHRNB2 (0.42) | DPP4DPP8DPP9CHRNB2CHRNA4 | |
| SCHEMBL3542501 | 0.84 | CHRNB2 (0.42) | DPP4DPP8DPP9CHRNB2CHRNA4 | |
| SCHEMBL729546 | 0.84 | CHRNB2 (0.42) | DPP4DPP8DPP9CHRNB2CHRNA4 | |
| SCHEMBL699327 | 0.84 | CHRNB2 (0.42) | DPP4DPP8DPP9CHRNB2CHRNA4 | |
| SCHEMBL21673908 | 0.82 | DPP4 (0.41) | DPP4DPP8DPP9CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125113-A2 | TERTIARY AMINE SUBSTITUTED PEPTIDES USEFUL AS INHIBITORS OF HCV REPLICATION | Achillion Pharmaceuticals, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008106130-A2 | TERTIARY AMINE SUBSTITUTED PEPTIDES USEFUL AS INHIBITORS OF HCV REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |