Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.72 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.54 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5443674 | 0.87 | HRH3 (0.74) | HRH3EPHX2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL12655872 | 0.86 | HRH3 (0.69) | HRH3EPHX2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14413613 | 0.86 | HRH3 (0.70) | HRH3EPHX2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5466723 | 0.85 | HRH3 (0.71) | HRH3EPHX2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL12655777 | 0.84 | MAPT (0.58) | HRH3EPHX2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5466560 | 0.84 | HRH3 (1.00) | HRH3EPHX2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL12655881 | 0.84 | HRH3 (0.66) | HRH3EPHX2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL12655412 | 0.83 | FAAH (0.70) | HRH3EPHX2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13873318 | 0.82 | EPHX2 (1.00) | HRH3EPHX2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL12655415 | 0.82 | HRH3 (0.67) | HRH3EPHX2KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137549-A1 | Novel compounds useful for the treatment of degenerative & inflamatory diseases | GALAPAGOS NV (BE) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137549-A1 | Novel compounds useful for the treatment of degenerative & inflamatory diseases | PDE4A, PDE7B, PDE4B | HRH3 4094/4885EPHX2 2459/4885KMT2A 3190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.