Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.30 |
| ▸ | CA12 | O43570 | 2/20 | 0.30 |
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12160052 | 0.82 | HDAC6 (0.40) | HDAC6HDAC1HDAC2DGAT1CTSD | |
| SCHEMBL3422429 | 0.79 | DGAT1 (0.39) | HDAC6HDAC1HDAC2DGAT1NFKB1 | |
| SCHEMBL5033844 | 0.76 | HDAC6 (0.37) | HDAC6HDAC1HDAC2DGAT1CTSS | |
| SCHEMBL23425907 | 0.76 | HDAC6 (0.41) | HDAC6HDAC1HDAC2DGAT1NFKB1 | |
| SCHEMBL3423603 | 0.76 | CA14 (0.34) | HDAC6HDAC1HDAC2DGAT1CTSS | |
| SCHEMBL8522505 | 0.75 | HDAC6 (0.38) | HDAC6HDAC1HDAC2DGAT1CA14 | |
| SCHEMBL4659197 | 0.75 | HDAC6 (0.36) | HDAC6HDAC1HDAC2DGAT1NFKB1 | |
| SCHEMBL24443453 | 0.74 | HDAC6 (0.34) | HDAC6HDAC1HDAC2NFKB1NFKB2 | |
| SCHEMBL7492517 | 0.74 | — | — | |
| SCHEMBL4960467 | 0.73 | HDAC6 (0.35) | HDAC6HDAC1HDAC2NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114158-A1 | 3-SUBSTITUTED-[1,2,3]BENZOTRIAZINONE COMPOUNDS FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | CORTEX PHARMACEUTICALS, INC. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008085505-A1 | 3-SUBSTITUTED-[1,2,3]BENZOTRIAZINONE COMPOUNDS FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | CORTEX PHARMACEUTICALS, INC. (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2005042481-A2 | COMPOUNDS AND RELATED METHODS FOR MUTANT p53 REACTIVATION | NORTHWESTERN UNIVERSITY (US) | 2005-05-12 | — | — | WO | disclosed |