Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | GHSR | Q92847 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MLNR | O43193 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31318430 | 1.00 | CYP2D6 (0.55) | CYP2D6MEN1LMNATP53KMT2A | |
| SCHEMBL3955961 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL572722 | 0.92 | FDPS (0.46) | CYP2D6MEN1LMNATP53KMT2A | |
| SCHEMBL12090068 | 0.83 | CYP2D6 (0.59) | CYP2D6MEN1LMNATP53KMT2A | |
| SCHEMBL7122727 | 0.83 | CYP2D6 (0.59) | CYP2D6MEN1LMNATP53KMT2A | |
| SCHEMBL6962061 | 0.83 | CYP2D6 (0.59) | CYP2D6MEN1LMNATP53KMT2A | |
| SCHEMBL29776880 | 0.82 | — | — | |
| SCHEMBL18648051 | 0.81 | CYP2D6 (0.62) | CYP2D6MEN1LMNATP53KMT2A | |
| SCHEMBL25819757 | 0.81 | CYP2D6 (0.62) | CYP2D6MEN1LMNATP53KMT2A | |
| SCHEMBL15594567 | 0.80 | CYP2D6 (0.52) | CYP2D6MEN1LMNATP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527846-B2 | Kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-12-27 | — | — | US | disclosed |
| EP-2788349-B1 | KINASE INHIBITORS | CHIESI FARMA SPA (IT) | 2016-10-26 | — | — | EP | disclosed |
| US-20160229852-A1 | KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-08-11 | — | — | US | disclosed |
| US-9315503-B2 | Kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-04-19 | — | — | US | disclosed |
| US-20150344475-A1 | KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-03 | — | — | US | disclosed |
| US-9145413-B2 | Kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-09-29 | — | — | US | disclosed |
| US-9139584-B2 | Kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-09-22 | — | — | US | disclosed |
| US-20150080375-A1 | KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-03-19 | — | — | US | disclosed |
| US-8907094-B2 | Kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-12-09 | — | — | US | disclosed |
| US-20140323470-A1 | KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-10-30 | — | — | US | disclosed |
| US-8871317-B2 | Curable adhesive system, method of assembly of distinct components therewith | TEKNOR APEX COMPANY (US) | 2014-10-28 | — | — | US | disclosed |
| EP-2788349-A1 | KINASE INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2014-10-15 | — | — | EP | disclosed |
| EP-2613933-A2 | CURABLE ADHESIVE SYSTEM, METHOD OF ASSEMBLY OF DISTINCT COMPONENTS THEREWITH | Teknor Apex Company (US) | 2013-07-17 | — | — | EP | disclosed |
| WO-2013083604-A1 | KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-06-13 | — | — | WO | disclosed |
| US-20130150343-A1 | KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-06-13 | — | — | US | disclosed |
| WO-2012033519-A2 | CURABLE ADHESIVE SYSTEM, METHOD OF ASSEMBLY OF DISTINCT COMPONENTS THEREWITH | TEKNOR APEX COMPANY (US) | 2012-03-15 | — | — | WO | disclosed |
| US-20120064274-A1 | Curable adhesive system, method of assembly of distinct components therewith | TEKNOR APEX COMPANY (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344475-A1 | KINASE INHIBITORS | MAPK1, MAP3K1, MAPK6 | CYP2D6 927/4885MEN1 4327/4885LMNA 2358/4885 |
| US-20160229852-A1 | KINASE INHIBITORS | MAPK1, MAP3K1, MAPK6 | CYP2D6 927/4885MEN1 4327/4885LMNA 2358/4885 |
| US-20150080375-A1 | KINASE INHIBITORS | MAPK1, MAP3K1, MAPK6 | CYP2D6 927/4885MEN1 4327/4885LMNA 2358/4885 |
| US-20140323470-A1 | KINASE INHIBITORS | MAPK1, MAP3K1, MAPK6 | CYP2D6 927/4885MEN1 4327/4885LMNA 2358/4885 |
| US-20130150343-A1 | KINASE INHIBITORS | MAPK1, MAP3K1, MAPK6 | CYP2D6 927/4885MEN1 4327/4885LMNA 2358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.