Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 10/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4534412 | 0.86 | FASN (0.70) | FASNGSK3BCHRM5HTR7HTR6 | |
| SCHEMBL15543513 | 0.77 | FASN (0.46) | FASNGSK3BROCK2MET | |
| SCHEMBL4538762 | 0.76 | FASN (0.67) | FASNROCK2CHRM5HTR7HTR6 | |
| SCHEMBL15544134 | 0.76 | FASN (0.45) | FASNGSK3BROCK2MET | |
| SCHEMBL4566498 | 0.74 | FASN (0.42) | FASN | |
| SCHEMBL14720295 | 0.73 | FASN (0.43) | FASNGSK3BMET | |
| SCHEMBL4539663 | 0.73 | FASN (0.73) | FASNCHRM5HTR7HTR6 | |
| SCHEMBL15239171 | 0.73 | FASN (0.69) | FASNGSK3BCHRM5HTR7HTR6 | |
| SCHEMBL15239145 | 0.72 | FASN (0.73) | FASNCHRM5HTR7HTR6 | |
| SCHEMBL4540768 | 0.72 | FASN (0.71) | FASNCHRM5HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | claimed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | claimed |