Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.62 |
| ▸ | GSK3B | P49841 | 8/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.62 |
| ▸ | CLK2 | P49760 | 8/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 7/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.62 |
| ▸ | GSK3A | P49840 | 7/20 | 0.62 |
| ▸ | KDR | P35968 | 7/20 | 0.62 |
| ▸ | STK17A | Q9UEE5 | 7/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 6/20 | 0.62 |
| ▸ | CDK2 | P24941 | 6/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.62 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.62 |
| ▸ | FLT4 | P35916 | 4/20 | 0.62 |
| ▸ | BRSK1 | Q8TDC3 | 4/20 | 0.62 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.62 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.62 |
| ▸ | PLK4 | O00444 | 2/20 | 0.62 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1421498 | 0.93 | CLK4 (0.70) | CLK4GSK3BCDK5CLK2MAP4K4 | |
| SCHEMBL3802577 | 0.93 | CLK4 (0.70) | CLK4GSK3BCDK5CLK2MAP4K4 | |
| SCHEMBL1421049 | 0.84 | GSK3B (0.70) | CLK4GSK3BCDK5CLK2MAP4K4 | |
| SCHEMBL4561277 | 0.82 | GSK3B (0.41) | CLK4GSK3BCDK5CLK2MAP4K4 | |
| SCHEMBL10296674 | 0.81 | CLK4 (0.71) | CLK4GSK3BCDK5CLK2MAP4K4 | |
| SCHEMBL12663381 | 0.78 | CLK4 (0.54) | CLK4GSK3BCDK5CLK2MAP4K4 | |
| SCHEMBL10296641 | 0.78 | GSK3B (0.67) | CLK4GSK3BCDK5CLK2MAP4K4 | |
| SCHEMBL10008353 | 0.78 | CLK2 (0.70) | CLK4GSK3BCDK5CLK2MAP4K4 | |
| SCHEMBL12663382 | 0.78 | GSK3B (0.59) | CLK4GSK3BCDK5CLK2MAP4K4 | |
| SCHEMBL3802860 | 0.77 | CLK4 (1.00) | CLK4GSK3BCDK5CLK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091943-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | Abbott GmbH & Co. KG (DE) | 2009-08-26 | — | — | EP | claimed |
| WO-2008046919-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2008-04-24 | — | — | WO | claimed |
| EP-2091943-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | Abbott GmbH & Co. KG (DE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008046919-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2008-04-24 | — | — | WO | disclosed |