Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.41 |
| ▸ | GSK3A | P49840 | 4/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CLK2 | P49760 | 3/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561276 | 0.82 | CLK4 (0.62) | GSK3BCDK5KDRCLK4GSK3A | |
| SCHEMBL1421498 | 0.74 | CLK4 (0.70) | GSK3BCDK5KDRCLK4GSK3A | |
| SCHEMBL3802577 | 0.74 | CLK4 (0.70) | GSK3BCDK5KDRCLK4GSK3A | |
| SCHEMBL4562088 | 0.69 | GSK3B (0.45) | GSK3BCDK5KDRCLK4GSK3A | |
| SCHEMBL1421049 | 0.68 | GSK3B (0.70) | GSK3BCDK5KDRCLK4GSK3A | |
| SCHEMBL12663382 | 0.63 | GSK3B (0.59) | GSK3BCDK5KDRCLK4GSK3A | |
| SCHEMBL22659957 | 0.63 | ALK (0.46) | KMT2AMEN1RAB9ANPC1GRM5 | |
| SCHEMBL29016187 | 0.62 | KMT2A (0.74) | CDK2LRRK2KMT2AMEN1NPSR1 | |
| SCHEMBL29409256 | 0.62 | KMT2A (0.74) | CDK2LRRK2KMT2AMEN1NPSR1 | |
| SCHEMBL12663381 | 0.62 | CLK4 (0.54) | GSK3BCDK5KDRCLK4GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091943-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | Abbott GmbH & Co. KG (DE) | 2009-08-26 | — | — | EP | claimed |
| WO-2008046919-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2008-04-24 | — | — | WO | claimed |
| EP-2091943-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | Abbott GmbH & Co. KG (DE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008046919-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2008-04-24 | — | — | WO | disclosed |