Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | NAMPT | P43490 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27970107 | 0.91 | POLB (0.61) | POLBKMT2ATMEM97SIGMAR1HDAC3 | |
| SCHEMBL9489576 | 0.90 | NAMPT (0.73) | POLBKMT2ATMEM97SIGMAR1HDAC3 | |
| SCHEMBL16151772 | 0.85 | SMN1; SMN2 (0.69) | KMT2AHDAC3HDAC1KDM4ESMN1; SMN2 | |
| SCHEMBL13753747 | 0.84 | L3MBTL1 (0.65) | POLBKMT2ATMEM97SIGMAR1HDAC3 | |
| Hydrochloric Acid SCHEMBL16428996 | 0.83 | SMN1; SMN2 (0.67) | KMT2AHDAC3HDAC1KDM4ESMN1; SMN2 | |
| SCHEMBL16127281 | 0.82 | HDAC1 (0.68) | KMT2AHDAC3HDAC1NAMPTKDM4E | |
| SCHEMBL17027795 | 0.81 | POLB (0.63) | POLBKMT2ATMEM97SIGMAR1HDAC3 | |
| SCHEMBL18078704 | 0.81 | SMN1; SMN2 (0.73) | POLBKMT2AHDAC3KDM4ESMN1; SMN2 | |
| SCHEMBL12563712 | 0.81 | NPC1 (0.62) | POLBKMT2AHDAC3HDAC1KDM4E | |
| SCHEMBL13702275 | 0.80 | KDM4E (0.62) | POLBKMT2ATMEM97SIGMAR1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009148659-A2 | ANTIMALARIAL QUINOLINES AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2009-12-10 | — | — | WO | disclosed |