Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 7/20 | 0.56 |
| ▸ | TYK2 | P29597 | 5/20 | 0.56 |
| ▸ | JAK3 | P52333 | 5/20 | 0.56 |
| ▸ | JAK2 | O60674 | 5/20 | 0.56 |
| ▸ | STAT3 | P40763 | 3/20 | 0.56 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.46 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4560068 | 0.88 | JAK1 (0.58) | JAK1TYK2JAK3JAK2STAT3 | |
| SCHEMBL4561182 | 0.85 | JAK1 (0.52) | JAK1TYK2JAK3JAK2STAT3 | |
| SCHEMBL4561655 | 0.85 | JAK1 (0.52) | JAK1TYK2JAK3JAK2STAT3 | |
| SCHEMBL4561987 | 0.82 | LRRK2 (0.51) | JAK1TYK2JAK3JAK2STAT3 | |
| SCHEMBL4560600 | 0.82 | JAK1 (0.52) | JAK1TYK2JAK3JAK2STAT3 | |
| SCHEMBL4562522 | 0.81 | JAK2 (0.64) | JAK1TYK2JAK3JAK2STAT3 | |
| SCHEMBL4562360 | 0.81 | JAK3 (0.51) | JAK1TYK2JAK3JAK2STAT3 | |
| SCHEMBL4561835 | 0.80 | IGF1R (0.61) | JAK1TYK2JAK3JAK2STAT3 | |
| SCHEMBL31557681 | 0.80 | JAK1 (0.54) | JAK1TYK2JAK3JAK2STAT3 | |
| SCHEMBL22098008 | 0.80 | JAK1 (0.54) | JAK1TYK2JAK3JAK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | claimed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | claimed |
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |