Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.51 |
| ▸ | JAK1 | P23458 | 6/20 | 0.50 |
| ▸ | JAK3 | P52333 | 5/20 | 0.50 |
| ▸ | TYK2 | P29597 | 5/20 | 0.50 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | STAT3 | P40763 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.45 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4560068 | 0.88 | JAK1 (0.58) | LRRK2JAK1JAK3TYK2JAK2 | |
| SCHEMBL4561182 | 0.87 | JAK1 (0.52) | JAK1JAK3TYK2JAK2STAT3 | |
| SCHEMBL4561655 | 0.85 | JAK1 (0.52) | LRRK2JAK1JAK3TYK2JAK2 | |
| SCHEMBL4561841 | 0.82 | JAK1 (0.56) | JAK1JAK3TYK2JAK2STAT3 | |
| SCHEMBL4560600 | 0.82 | JAK1 (0.52) | JAK1JAK3TYK2JAK2STAT3 | |
| SCHEMBL4562287 | 0.81 | TYK2 (0.55) | LRRK2JAK1JAK3TYK2JAK2 | |
| SCHEMBL4562360 | 0.81 | JAK3 (0.51) | JAK1JAK3TYK2JAK2STAT3 | |
| SCHEMBL4539646 | 0.80 | JAK1 (0.48) | LRRK2JAK1JAK3TYK2JAK2 | |
| SCHEMBL4561835 | 0.80 | IGF1R (0.61) | JAK1JAK3TYK2JAK2STAT3 | |
| SCHEMBL22098006 | 0.80 | JAK1 (0.54) | JAK1JAK3TYK2JAK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | claimed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | claimed |
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |