Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 8/20 | 0.65 |
| ▸ | KDR | P35968 | 3/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.61 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.49 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | FES | P07332 | 2/20 | 0.41 |
| ▸ | ROS1 | P08922 | 2/20 | 0.41 |
| ▸ | FER | P16591 | 2/20 | 0.41 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348784 | 0.86 | CDK8 (0.63) | CDK8KDRFGFR1RIPK1AXL | |
| SCHEMBL11990128 | 0.83 | KDR (0.66) | CDK8KDRFGFR1RIPK1AXL | |
| SCHEMBL299515 | 0.81 | KDR (0.56) | CDK8KDRFGFR1RIPK1AXL | |
| SCHEMBL19891723 | 0.80 | KDR (0.62) | CDK8KDRFGFR1RIPK1AXL | |
| SCHEMBL3263731 | 0.79 | KDR (0.61) | CDK8KDRFGFR1RIPK1AXL | |
| SCHEMBL24240780 | 0.79 | KDR (0.56) | CDK8KDRFGFR1RIPK1AXL | |
| SCHEMBL91324 | 0.79 | KDR (0.60) | CDK8KDRFGFR1RIPK1AXL | |
| SCHEMBL1869919 | 0.79 | CDK8 (0.63) | CDK8KDRFGFR1RIPK1AXL | |
| SCHEMBL11968468 | 0.79 | KDR (0.56) | CDK8KDRFGFR1RIPK1AXL | |
| SCHEMBL29858603 | 0.79 | KDR (0.60) | CDK8KDRFGFR1RIPK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038272-A2 | PYRIDINONYL PDK1 INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008005457-A2 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS (US) | 2008-01-10 | — | — | WO | disclosed |