Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.61 |
| ▸ | CDK8 | P49336 | 7/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19891723 | 0.95 | KDR (0.62) | KDRFGFR1CDK8AXLPIK3CD | |
| SCHEMBL11990128 | 0.89 | KDR (0.66) | KDRFGFR1CDK8AXLPIK3CD | |
| SCHEMBL18007157 | 0.83 | RIPK1 (0.56) | KDRFGFR1CDK8AXLPIK3CD | |
| SCHEMBL29858603 | 0.82 | KDR (0.60) | KDRFGFR1CDK8AXLPIK3CD | |
| SCHEMBL91324 | 0.82 | KDR (0.60) | KDRFGFR1CDK8AXLPIK3CD | |
| SCHEMBL4562744 | 0.79 | CDK8 (0.65) | KDRFGFR1CDK8AXLPIK3CD | |
| SCHEMBL1873717 | 0.78 | KDR (0.53) | KDRFGFR1CDK8AXLRIPK1 | |
| SCHEMBL1574435 | 0.78 | PTGS2 (0.38) | KDRFGFR1TDP1L3MBTL1 | |
| SCHEMBL298631 | 0.76 | KDR (0.52) | KDRFGFR1CDK8AXLRIPK1 | |
| SCHEMBL10283341 | 0.76 | KDR (0.55) | KDRFGFR1CDK8AXLPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470849-B2 | 7-azaindole derivatives as selective 11-β-hydroxysteroid dehydrogenase type 1 inhibitors | MERCK PATENT GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| EP-2247589-B1 | 7-AZAINDOLE DERIVATIVES AS SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | MERCK PATENT GMBH (DE) | 2012-11-21 | — | — | EP | disclosed |
| EP-2247589-A1 | 7-AZAINDOLE DERIVATIVES AS SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Merck Patent GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| US-20100267761-A1 | 7-Azaindole Derivatives as Selective 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors | MERCK PATENT GESELLSCHAFT | 2010-10-21 | — | — | US | disclosed |
| WO-2009059666-A1 | 7-AZAINDOLE DERIVATIVES AS SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | MERCK PATENT GMBH (DE) | 2009-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267761-A1 | 7-Azaindole Derivatives as Selective 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors | HSD11B1, HSD17B1, HSD11B2 | KDR 4126/4885FGFR1 4304/4885CDK8 3341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.