Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.38 |
| ▸ | CDK9 | P50750 | 7/20 | 0.38 |
| ▸ | NPY1R | P25929 | 6/20 | 0.36 |
| ▸ | CDK4 | P11802 | 3/20 | 0.32 |
| ▸ | CDK7 | P50613 | 3/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.31 |
| ▸ | CCND1 | P24385 | 2/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.31 |
| ▸ | CCNH | P51946 | 2/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.31 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.31 |
| ▸ | TTK | P33981 | 3/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30638 | 0.83 | NPY1R (0.30) | NPY1R | |
| SCHEMBL7883676 | 0.70 | CDK2 (0.35) | CDK2 | |
| SCHEMBL16104577 | 0.68 | HSD17B10 (0.38) | GSK3B | |
| SCHEMBL588833 | 0.68 | CCNT1 (0.39) | CDK2CDK9CDK4CDK7CCNT1 | |
| SCHEMBL7874241 | 0.67 | TTK (0.33) | TTK | |
| SCHEMBL29141 | 0.66 | NTRK1 (0.32) | — | |
| SCHEMBL45819 | 0.65 | PDE1A (0.31) | PDE1BPDE1C | |
| SCHEMBL15026310 | 0.63 | TTK (0.39) | CDK2CDK9TTK | |
| SCHEMBL31400 | 0.63 | TTK (0.39) | CDK2CDK9TTK | |
| SCHEMBL7883776 | 0.61 | NPC1 (0.36) | TTKGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |