Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29141 | 0.80 | NTRK1 (0.32) | — | |
| SCHEMBL30638 | 0.80 | NPY1R (0.30) | — | |
| SCHEMBL588833 | 0.76 | CCNT1 (0.39) | — | |
| SCHEMBL39678 | 0.74 | — | — | |
| SCHEMBL45628 | 0.65 | CDK2 (0.38) | PDE1BPDE1C | |
| SCHEMBL29142 | 0.65 | MET (0.32) | PDE1B | |
| SCHEMBL29251 | 0.63 | MEN1 (0.32) | — | |
| SCHEMBL31291 | 0.63 | POLB (0.31) | — | |
| SCHEMBL15007405 | 0.62 | — | — | |
| SCHEMBL6890894 | 0.61 | JAK1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |