Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4484544 | 0.76 | KDM4E (0.63) | KDM4ERECQLOPRL1OPRM1GAA | |
| SCHEMBL18061244 | 0.70 | KDM4E (0.46) | KDM4ERECQLOPRL1OPRM1GAA | |
| SCHEMBL17858470 | 0.69 | KDM4E (0.44) | KDM4ERECQLOPRL1OPRM1GAA | |
| SCHEMBL3691840 | 0.68 | GAA (0.50) | KDM4EOPRL1GAACA12CA9 | |
| SCHEMBL4480156 | 0.67 | CA2 (0.43) | KDM4ERECQLOPRL1OPRM1GAA | |
| SCHEMBL22957062 | 0.66 | OPRL1 (0.46) | KDM4ERECQLOPRL1OPRM1GAA | |
| SCHEMBL22292512 | 0.63 | OPRL1 (0.42) | KDM4ERECQLOPRL1OPRM1GAA | |
| SCHEMBL13292328 | 0.63 | OPRL1 (0.39) | KDM4ERECQLOPRL1OPRM1GAA | |
| SCHEMBL11807225 | 0.63 | KDM4E (0.70) | KDM4ERECQLGAACA12CA9 | |
| SCHEMBL17854058 | 0.63 | OPRL1 (0.40) | KDM4ERECQLOPRL1OPRM1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |