SCHEMBL4563366

SCHEMBL4563366

Cc1cnc(-c2ccc(Cl)cc2Cl)n1-c1ccc(Cl)cc1

nearest known ligand 0.54

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.54
HSD11B1 P28845 2/20 0.50
POLB P06746 2/20 0.50
MEN1 O00255 1/20 0.48
CNR1 P21554 7/20 0.46
KCNH2 Q12809 1/20 0.46
CNR2 P34972 4/20 0.46
OPRL1 P41146 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12064374 0.91 CNR1 (0.47) KMT2AHSD11B1POLBMEN1CNR1
SCHEMBL12064305 0.88 POLB (0.43) KMT2AHSD11B1POLBMEN1CNR1
SCHEMBL4563433 0.84 KMT2A (0.50) KMT2AHSD11B1POLBMEN1CNR1
SCHEMBL12064373 0.84 ROS1 (0.46) KMT2AHSD11B1POLBMEN1KCNH2
SCHEMBL12064306 0.83 HSD11B1 (0.45) KMT2AHSD11B1POLBMEN1CNR1
SCHEMBL12064307 0.83 HSD11B1 (0.48) KMT2AHSD11B1POLBMEN1CNR1
SCHEMBL4618665 0.82 CNR1 (0.55) KMT2AMEN1CNR1
SCHEMBL12064304 0.82 POLB (0.44) KMT2AHSD11B1POLBMEN1CNR1
SCHEMBL4563605 0.80 KMT2A (0.47) KMT2AHSD11B1POLBMEN1CNR1
SCHEMBL4562966 0.80 KMT2A (0.49) KMT2AHSD11B1POLBMEN1CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2026798-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING CBX CANNABINOID RECEPTOR MODULATORS AND POTASSIUM CHANNEL MODULATORS Solvay Pharmaceuticals GmbH (DE) 2009-02-25 EP disclosed
WO-2007125048-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING CBX CANNABINOID RECEPTOR MODULATORS AND POTASSIUM CHANNEL MODULATORS SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-08 WO disclosed