Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584923 | 0.92 | PTGER4 (0.40) | PTGER4PRKCAMMP12CNR2KDM4E | |
| SCHEMBL2279301 | 0.82 | KCNH2 (0.40) | CNR2MAPTHPGDNR1I2SCN9A | |
| SCHEMBL3583062 | 0.81 | PRKCA (0.41) | PTGER4PRKCAMMP12CNR2KDM4E | |
| SCHEMBL3589949 | 0.81 | PRKCA (0.40) | PTGER4PRKCAMMP12CNR2KDM4E | |
| SCHEMBL3585949 | 0.80 | PRKCA (0.37) | PTGER4PRKCAMMP12CNR2KDM4E | |
| SCHEMBL3586034 | 0.79 | PRKCA (0.38) | PRKCAMMP12CNR2KDM4EHPGD | |
| SCHEMBL4829898 | 0.77 | SCN9A (0.38) | PTGER4PRKCAMMP12CNR2KDM4E | |
| SCHEMBL14435483 | 0.77 | PRKCA (0.35) | PRKCAMMP12CNR2KDM4EHPGD | |
| SCHEMBL14263720 | 0.77 | PRKCA (0.35) | PRKCAMMP12CNR2KDM4EHPGD | |
| SCHEMBL4825640 | 0.75 | KDM4E (0.40) | PTGER4PRKCAMMP12CNR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027125-A1 | PENTACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007129119-A1 | PENTACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-11-15 | — | — | WO | disclosed |