SCHEMBL456349

SCHEMBL456349

Clc1[c]cccc1-c1ccccc1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.44
DPP4 P27487 2/20 0.42
LMNA P02545 2/20 0.39
TSHR P16473 2/20 0.39
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
TP53 P04637 2/20 0.39
HPGD P15428 1/20 0.39
PTPRC P08575 1/20 0.38
MAOB P27338 2/20 0.37
POLB P06746 1/20 0.37
KMT2A Q03164 1/20 0.37
PLA2G7 Q13093 1/20 0.37
ALDH1A1 P00352 3/20 0.36
HSD11B1 P28845 1/20 0.36
CYP19A1 P11511 1/20 0.36
IDO1 P14902 1/20 0.35
NOTUM Q6P988 2/20 0.35
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5584101 0.88 IDO1 (0.32) CYP2A6IDO1
SCHEMBL15636895 0.83 NOTUM (0.39) TSHRIDO1NOTUM
SCHEMBL8560761 0.80 CYP2A6 (0.43) CYP2A6DPP4LMNATSHRNPC1
SCHEMBL15635850 0.80 CYP2A6 (0.33) CYP2A6LMNATSHR
SCHEMBL432622 0.79 AHR (0.42) TSHRNPC1RAB9ASMN1; SMN2TP53
SCHEMBL15637578 0.79 KMO (0.39) CYP2A6IDO1
SCHEMBL15637039 0.79 PTPN1 (0.40) TSHRSMN1; SMN2TP53HPGDKMT2A
SCHEMBL15666423 0.78 CYP2A6 (0.41) CYP2A6DPP4LMNATSHRNPC1
SCHEMBL6226779 0.78 NPC1 (0.39) TSHRNPC1RAB9ASMN1; SMN2HPGD
SCHEMBL21224461 0.78 DPP4 (0.44) CYP2A6DPP4LMNATSHRNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1423119-A4 HETEROBICYCLES FKBP-LIGANDS AGOURON PHARMA (US) 2005-04-13 EP claimed
EP-1423119-A1 HETEROBICYCLES FKBP-LIGANDS Agouron Pharmaceuticals, Inc. (US) 2004-06-02 EP claimed
WO-2002089806-A1 HETEROBICYCLES FKBP-LIGANDS AGOURON PHARMACEUTICALS, INC. (US) 2002-11-14 WO claimed
EP-3126335-A1 N-(1-(HETERO)ARYL-1H-PYRAZOL-4-YL)-(HETERO)ARYLAMIDE DERIVATIVES AND USE THEREOF AS PESTICIDES Bayer CropScience Aktiengesellschaft (DE) 2017-02-08 EP disclosed
WO-2015150300-A1 N-(1-(HETERO)ARYL-1H-PYRAZOL-4-YL)-(HETERO)ARYLAMIDE DERIVATIVES AND USE THEREOF AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2015-10-08 WO disclosed
EP-2903440-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES Bayer CropScience AG (DE) 2015-08-12 EP disclosed
WO-2014053450-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2014-04-10 WO disclosed
EP-2614053-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2013-07-17 EP disclosed
WO-2012033225-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-03-15 WO disclosed
CN-1162404-C Process for the synthesis of intermediates useful in the preparation of tricyclic compounds 先灵公司 2004-08-18 CN disclosed
CN-1326444-A Process for the synthesis of intermediates useful in the preparation of tricyclic compounds SCHERING CORP (US) 2001-12-12 CN disclosed
US-4943583-A PESTICIDES HOFFMANN-LA ROCHE INC. (US) 1990-07-24 US disclosed
US-4923781-A STORAGE STABILITY, CONTRAST, HIGH DENSITY, PHOTOSENSITIVITY FUJI PHOTO FILM CO., LTD. (JP) 1990-05-08 US disclosed
US-4871757-A PESTICIDES HOFFMANN-LA ROCHE INC. (US) 1989-10-03 US disclosed
US-4524168-A AZO DYES CIBA-GEIGY CORPORATION (US) 1985-06-18 US disclosed
US-4205087-A ANTIARTHRITIC AGENTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-05-27 US disclosed