Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.58 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.58 |
| ▸ | ALPI | P09923 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | XIAP | P98170 | 1/20 | 0.57 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | GSR | P00390 | 1/20 | 0.51 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amphetamine SCHEMBL27917387 | 0.95 | GSR (0.59) | SLC6A2TAAR1MAOASLC6A4SLC6A3 | |
| Amphetamine SCHEMBL578976 | 0.95 | GSR (0.59) | SLC6A2TAAR1MAOASLC6A4SLC6A3 | |
| Amphetamine SCHEMBL28843066 | 0.95 | GSR (0.59) | SLC6A2TAAR1MAOASLC6A4SLC6A3 | |
| Amphetamine SCHEMBL578608 | 0.95 | GSR (0.59) | SLC6A2TAAR1MAOASLC6A4SLC6A3 | |
| Amphetamine SCHEMBL969267 | 0.94 | GSR (0.57) | SLC6A2TAAR1MAOASLC6A4SLC6A3 | |
| Dextroamphetamine SCHEMBL19873157 | 0.89 | THRB (0.59) | SLC6A2TAAR1MAOASLC6A4SLC6A3 | |
| Amphetamine SCHEMBL969812 | 0.89 | THRB (0.59) | SLC6A2TAAR1MAOASLC6A4SLC6A3 | |
| Amphetamine SCHEMBL27878191 | 0.89 | THRB (0.59) | SLC6A2TAAR1MAOASLC6A4SLC6A3 | |
| Amphetamine SCHEMBL973960 | 0.89 | THRB (0.59) | SLC6A2TAAR1MAOASLC6A4SLC6A3 | |
| Dl-Phenylalanine SCHEMBL4361765 | 0.89 | SLC7A5 (0.73) | ALPIPKMPTGS1XIAPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101594778-A | Non-standard amino acid conjugates of amphetamine and methods of making and using same | KEMPHARM INC (US) | 2009-12-02 | — | — | CN | disclosed |
| EP-2101571-A1 | NON-STANDARD AMINO ACID CONJUGATES OF AMPHETAMINE AND PROCESSES FOR MAKING AND USING THE SAME | Kempharm, Inc. (US) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008073918-A1 | NON-STANDARD AMINO ACID CONJUGATES OF AMPHETAMINE AND PROCESSES FOR MAKING AND USING THE SAME | KEMPHARM, INC. (US) | 2008-06-19 | — | — | WO | disclosed |