Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 16/20 | 0.77 |
| ▸ | HHAT | Q5VTY9 | 2/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3068287 | 1.00 | TRPM8 (0.77) | TRPM8HHATHDAC3HDAC1HDAC8 | |
| SCHEMBL3074733 | 0.87 | TRPM8 (1.00) | TRPM8HDAC3HDAC1HDAC8NCOR2 | |
| SCHEMBL13089810 | 0.87 | TRPM8 (0.76) | TRPM8HDAC3HDAC1HDAC8NCOR2 | |
| SCHEMBL3073681 | 0.86 | TRPM8 (0.72) | TRPM8HDAC3HDAC1HDAC8NCOR2 | |
| SCHEMBL3064661 | 0.85 | TRPM8 (0.70) | TRPM8HDAC3HDAC1HDAC8NCOR2 | |
| SCHEMBL3072906 | 0.84 | TRPM8 (0.69) | TRPM8HDAC3HDAC1HDAC8NCOR2 | |
| SCHEMBL3057149 | 0.84 | TRPM8 (1.00) | TRPM8 | |
| SCHEMBL3057157 | 0.84 | TRPM8 (1.00) | TRPM8 | |
| SCHEMBL3057153 | 0.84 | TRPM8 (1.00) | TRPM8 | |
| SCHEMBL13089816 | 0.84 | TRPM8 (0.86) | TRPM8HDAC3HDAC1HDAC8NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009073203-A1 | TRP-M8 RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2009-06-11 | — | — | WO | disclosed |