Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK3 | P52333 | 4/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4563609 | 0.88 | NAMPT (0.43) | HRH3NAMPTCYP3A4CYP2C9HDAC1 | |
| SCHEMBL14012694 | 0.80 | HRH3 (0.47) | HRH3NAMPTSLC18A3OPRM1KDM1A | |
| SCHEMBL4564074 | 0.79 | SIGMAR1 (0.47) | HRH3NAMPTOPRM1SIGMAR1 | |
| SCHEMBL5805849 | 0.75 | HRH3 (0.45) | HRH3SLC18A3OPRM1KDM1A | |
| SCHEMBL14012682 | 0.75 | HRH3 (0.46) | HRH3SLC18A3OPRM1KDM1AOPRL1 | |
| SCHEMBL4564154 | 0.74 | HRH3 (0.43) | HRH3SLC18A3OPRM1KDM1A | |
| SCHEMBL14012686 | 0.72 | MAPT (0.45) | HRH3SIGMAR1 | |
| SCHEMBL5067024 | 0.71 | MCHR1 (0.48) | — | |
| SCHEMBL5821272 | 0.71 | HRH3 (0.40) | HRH3CARM1 | |
| SCHEMBL5805777 | 0.70 | SIGMAR1 (0.41) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137158-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES (PRMTS) | MethylGene Inc. (CA) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008104077-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES (PRMTS) | METHYLGENE INC. (CA) | 2008-09-04 | — | — | WO | disclosed |