Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | CTSG | P08311 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310156 | 0.78 | GABRA1 (0.47) | GABRA1GABRB2 | |
| SCHEMBL1933231 | 0.77 | — | — | |
| SCHEMBL11731891 | 0.77 | — | — | |
| SCHEMBL24554 | 0.76 | GABRA1 (0.45) | GABRA1GABRB2 | |
| SCHEMBL919938 | 0.76 | GABRA1 (0.45) | GABRA1GABRB2 | |
| SCHEMBL5504187 | 0.74 | — | — | |
| SCHEMBL9359703 | 0.73 | GABRA1 (0.37) | GABRA1GABRB2ELANECTSG | |
| SCHEMBL4562779 | 0.72 | GABRA1 (0.41) | GABRA1GABRB2ELANECTSG | |
| SCHEMBL1664569 | 0.72 | GABRA1 (0.41) | GABRA1GABRB2 | |
| SCHEMBL864085 | 0.72 | GABRA1 (1.00) | GABRA1GABRB2KDM4EUSP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121672-A2 | SUBSTITUTED GAMMA LACTAMS AS THERAPEUTIC AGENTS | Allergan, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008094912-A2 | SUBSTITUTED GAMMA LACTAMS AS THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 2008-08-07 | — | — | WO | disclosed |