Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 11/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457969 | 0.80 | TTK (0.45) | TTK | |
| SCHEMBL456417 | 0.73 | TTK (0.57) | TTK | |
| SCHEMBL18208911 | 0.71 | TTK (0.39) | TTKKMT2API4KB | |
| SCHEMBL469904 | 0.70 | TTK (0.55) | TTK | |
| SCHEMBL456371 | 0.69 | TTK (0.46) | TTK | |
| SCHEMBL18208715 | 0.68 | TTK (0.36) | TTK | |
| SCHEMBL456964 | 0.68 | TTK (0.36) | TTK | |
| SCHEMBL457466 | 0.67 | TTK (0.41) | TTK | |
| SCHEMBL457970 | 0.66 | TTK (0.44) | TTK | |
| SCHEMBL456366 | 0.66 | ERN1 (0.34) | TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614063-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |