Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 7/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 5/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12467105 | 0.90 | MAPK8 (0.36) | TTKSYKMAPK8TYK2 | |
| SCHEMBL457969 | 0.88 | TTK (0.45) | TTK | |
| SCHEMBL457466 | 0.77 | TTK (0.41) | TTK | |
| SCHEMBL12466787 | 0.75 | ERN1 (0.39) | TTKSYKERN1TYK2 | |
| SCHEMBL456965 | 0.72 | ERN1 (0.40) | TTKERN1 | |
| SCHEMBL459378 | 0.71 | TTK (0.57) | TTKERN1 | |
| SCHEMBL469904 | 0.70 | TTK (0.55) | TTK | |
| SCHEMBL456370 | 0.68 | TTK (0.41) | TTK | |
| SCHEMBL458996 | 0.68 | ERN1 (0.36) | ERN1 | |
| SCHEMBL17560053 | 0.67 | TTK (0.42) | TTKSYKMAPK8TYK2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614063-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |