Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570039 | 0.79 | AKT1 (0.37) | HTTPIK3CBMAPTHSD17B10KDM4E | |
| SCHEMBL4564984 | 0.77 | AKT1 (0.36) | HTTPIK3CBMAPTHSD17B10KDM4E | |
| SCHEMBL4564882 | 0.77 | PIK3CB (0.39) | HTTPIK3CBPIK3CAPIK3CDPIK3R1 | |
| SCHEMBL4465034 | 0.76 | PIK3CB (0.36) | HTTPIK3CBPIK3CAPIK3CDPIK3R1 | |
| SCHEMBL4564983 | 0.76 | PIK3CD (0.40) | PIK3CBMAPTHSD17B10KDM4EALDH1A1 | |
| SCHEMBL4472229 | 0.75 | PIK3CB (0.36) | HTTPIK3CBPIK3CAPIK3CDPIK3R1 | |
| SCHEMBL4478719 | 0.75 | PIK3CB (0.36) | HTTPIK3CBNPSR1KDM4EALDH1A1 | |
| SCHEMBL4477321 | 0.74 | PIK3CB (0.35) | HTTPIK3CBNPSR1MAPTTSHR | |
| SCHEMBL4473047 | 0.74 | PIK3CB (0.40) | HTTPIK3CBMAPTHSD17B10KDM4E | |
| SCHEMBL4466571 | 0.74 | PIK3CB (0.36) | HTTPIK3CBKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057147-A1 | PYRIMIDINE DERIVATIVES | Astra Zeneca AB (SE) | 2009-05-13 | — | — | EP | claimed |
| WO-2008032064-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |