Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570039 | 0.96 | AKT1 (0.37) | AKT1LMNAGBA1TP53POLB | |
| SCHEMBL4564983 | 0.81 | PIK3CD (0.40) | AKT1LMNAGBA1TP53POLB | |
| SCHEMBL4473047 | 0.78 | PIK3CB (0.40) | AKT1LMNAGBA1TP53POLB | |
| SCHEMBL4564097 | 0.77 | HTT (0.40) | AKT1MAPTPIK3CBPIK3CAPIK3CD | |
| SCHEMBL4469166 | 0.76 | PIK3CA (0.41) | LMNATP53POLBMAPTPIK3CB | |
| SCHEMBL4522890 | 0.76 | PIK3CB (0.69) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL4564882 | 0.74 | PIK3CB (0.39) | AKT1PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL3984371 | 0.74 | MTOR (0.46) | POLBMAPTPIK3CBPIK3CAPIK3CD | |
| SCHEMBL3987596 | 0.74 | MOK (0.38) | AKT1MAPTPIK3CBPIK3CAPIK3CD | |
| SCHEMBL4465034 | 0.74 | PIK3CB (0.36) | AKT1GBA1PIK3CBPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057147-A1 | PYRIMIDINE DERIVATIVES | Astra Zeneca AB (SE) | 2009-05-13 | — | — | EP | claimed |
| WO-2008032064-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |