Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.64 |
| ▸ | CDC25A | P30304 | 1/20 | 0.64 |
| ▸ | CDC25B | P30305 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 9/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | DUSP26 | Q9BV47 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | TTR | P02766 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1789288 | 0.91 | CDC25A (0.75) | BACE1CDC25ACDC25BMAPTTP53 | |
| SCHEMBL3135247 | 0.90 | MAPT (0.70) | BACE1CDC25ACDC25BMAPTTP53 | |
| SCHEMBL4564720 | 0.88 | MAPT (0.58) | BACE1MAPTPOLBALDH1A1GFER | |
| SCHEMBL1790930 | 0.87 | CDC25A (0.77) | BACE1CDC25ACDC25BMAPTTP53 | |
| SCHEMBL1789256 | 0.85 | TTR (0.73) | BACE1CDC25ACDC25BMAPTTP53 | |
| SCHEMBL1788293 | 0.85 | MEN1 (0.68) | BACE1CDC25ACDC25BMAPTTP53 | |
| SCHEMBL1790988 | 0.85 | TTR (0.73) | BACE1CDC25ACDC25BMAPTTP53 | |
| SCHEMBL14050702 | 0.85 | CDC25A (0.67) | BACE1CDC25ACDC25BMAPTTP53 | |
| SCHEMBL1793225 | 0.85 | MAPT (0.71) | BACE1CDC25ACDC25BMAPTTP53 | |
| SCHEMBL1790028 | 0.85 | MEN1 (0.73) | BACE1CDC25ACDC25BMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |