Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.58 |
| ▸ | MEN1 | O00255 | 8/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | TTR | P02766 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1788588 | 0.91 | MEN1 (0.68) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4564217 | 0.88 | BACE1 (0.64) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL1789459 | 0.87 | MAPT (0.68) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL1792290 | 0.87 | SMN1; SMN2 (0.70) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL12292684 | 0.85 | MAPT (0.62) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL1788293 | 0.85 | MEN1 (0.68) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL1793450 | 0.85 | TTR (0.73) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL1792192 | 0.85 | MEN1 (0.73) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL1788654 | 0.85 | TTR (0.73) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL1789934 | 0.85 | MEN1 (0.68) | MAPTMEN1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| US-8481001-B2 | Combination therapies comprising quinoxaline inhibitors of P13K-alpha for use in the treatment of cancer | EXELIXIS, INC. (US) | 2013-07-09 | — | — | US | disclosed |