Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | FASN | P49327 | 4/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4565605 | 0.91 | MAPK14 (0.37) | HTR6FASNHTR7MAPK14LOXL2 | |
| SCHEMBL4564893 | 0.87 | FASN (0.35) | FASNMAPK14LOXL2GSK3B | |
| SCHEMBL4565347 | 0.85 | MAPK14 (0.35) | FASNMAPK14GSK3B | |
| SCHEMBL4564399 | 0.84 | FASN (0.37) | HTR6FASNHTR7LOXL2GSK3B | |
| SCHEMBL4565737 | 0.80 | GSK3B (0.37) | FASNMAPK14LOXL2GSK3B | |
| SCHEMBL4564691 | 0.80 | FASN (0.36) | FASNGSK3B | |
| SCHEMBL4565609 | 0.80 | FASN (0.38) | HTR6FASNHTR7GSK3B | |
| SCHEMBL4561087 | 0.79 | LOXL2 (0.33) | FASNMAPK14LOXL2GSK3B | |
| SCHEMBL4541625 | 0.78 | FASN (0.38) | HTR6FASNCYP1A2CYP3A4HTR1A | |
| SCHEMBL4561931 | 0.78 | FASN (0.41) | HTR6FASNMAPK14LOXL2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | disclosed |