Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | FADS1 | O60427 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203187 | 0.80 | NPC1 (0.46) | CSNK2A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2197137 | 0.78 | TGFBR1 (0.50) | MEN1KMT2ANPC1RAB9ATGFBR1 | |
| SCHEMBL4039259 | 0.73 | LRRK2 (0.47) | TGFBR1PRKD1RIPK3RIPK2KDR | |
| SCHEMBL2229449 | 0.71 | TGFBR1 (0.56) | TGFBR1PRKD1RIPK3RIPK2KDR | |
| SCHEMBL12259280 | 0.69 | LRRK2 (0.47) | CSNK2A1TGFBR1PRKD1RIPK3RIPK2 | |
| SCHEMBL4035827 | 0.69 | MEN1 (0.46) | CSNK2A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2201532 | 0.68 | KDR (0.47) | MEN1KMT2ATGFBR1PRKD1RIPK3 | |
| SCHEMBL2200375 | 0.67 | MAPT (0.50) | TGFBR1PRKD1RIPK3RIPK2KDR | |
| SCHEMBL4035715 | 0.67 | IKBKB (0.44) | MEN1KMT2ANPC1RAB9ATGFBR1 | |
| SCHEMBL2199804 | 0.66 | CSNK2A1 (0.50) | CSNK2A1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010173-A1 | COMPOUNDS FOR TREATING PULMONARY HYPERTENSION | Bayer HealthCare AG (DE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007118602-A1 | COMPOUNDS FOR TREATING PULMONARY HYPERTENSION | BAYER HEALTHCARE AG (DE) | 2007-10-25 | — | — | WO | disclosed |