Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.68 |
| ▸ | CDC25A | P30304 | 1/20 | 0.57 |
| ▸ | CDC25B | P30305 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 6/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 8/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4466855 | 0.89 | MAPT (0.71) | MAPTKDM4ECDC25ACDC25BGAA | |
| SCHEMBL1789260 | 0.85 | MAPT (0.77) | MAPTKDM4ECDC25ACDC25BGAA | |
| SCHEMBL1791384 | 0.85 | MAPT (0.76) | MAPTKDM4ECDC25ACDC25BGAA | |
| SCHEMBL1791160 | 0.83 | CDC25A (0.77) | MAPTKDM4ECDC25ACDC25BGAA | |
| SCHEMBL1789236 | 0.81 | MAPT (1.00) | MAPTKDM4EGAACTNNB1MEN1 | |
| SCHEMBL16239334 | 0.81 | MAPT (0.70) | MAPTKDM4ECDC25ACDC25BGAA | |
| SCHEMBL188789 | 0.76 | MEN1 (0.73) | MAPTKDM4ECDC25ACDC25BGAA | |
| SCHEMBL4342354 | 0.75 | PIK3CG (0.64) | MAPTKDM4EMEN1KMT2ALMNA | |
| SCHEMBL1788909 | 0.74 | PIK3CD (0.70) | MAPTKDM4ECDC25ACDC25BGAA | |
| SCHEMBL1794806 | 0.74 | TTR (0.82) | MAPTKDM4EGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |