Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | CDC25A | P30304 | 1/20 | 0.57 |
| ▸ | CDC25B | P30305 | 1/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 8/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.56 |
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1791384 | 0.90 | MAPT (0.76) | MAPTKDM4ECDC25ACDC25BCTNNB1 | |
| SCHEMBL1789260 | 0.86 | MAPT (0.77) | MAPTKDM4ECDC25ACDC25BCTNNB1 | |
| SCHEMBL1791160 | 0.86 | CDC25A (0.77) | MAPTKDM4ECDC25ACDC25BCTNNB1 | |
| SCHEMBL1789236 | 0.82 | MAPT (1.00) | MAPTKDM4ECTNNB1MEN1KMT2A | |
| SCHEMBL4564728 | 0.81 | MAPT (0.68) | MAPTKDM4ECDC25ACDC25BCTNNB1 | |
| SCHEMBL4564217 | 0.80 | BACE1 (0.64) | MAPTKDM4ECDC25ACDC25BMEN1 | |
| SCHEMBL4564720 | 0.80 | MAPT (0.58) | MAPTKDM4ECTNNB1MEN1KMT2A | |
| SCHEMBL188789 | 0.79 | MEN1 (0.73) | MAPTKDM4ECDC25ACDC25BCTNNB1 | |
| SCHEMBL27963145 | 0.78 | PIK3CD (0.78) | MAPTKDM4EMEN1KMT2AGAA | |
| SCHEMBL1790540 | 0.78 | MAPT (0.76) | MAPTKDM4ECDC25ACDC25BCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889664-B2 | Phosphatidylinositol 3-kinase inhibitors and methods of their use | EXELIXIS, INC. (US) | 2014-11-18 | — | — | US | disclosed |