Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL4565150 | 0.98 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Salicylic Acid SCHEMBL29599348 | 0.91 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL3942385 | 0.82 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL21494484 | 0.79 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL27650312 | 0.79 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL22463121 | 0.79 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL27310787 | 0.79 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL27838024 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL27633482 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL1319085 | 0.76 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDCA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137678-A1 | HIGH YIELD SYNTHESIS METHODS FOR PRODUCING ORGANIC SALTS OF STRONTIUM | OSTEOLOGIX A/S (DK) | 2009-05-28 | — | — | US | disclosed |
| EP-1899314-A2 | HIGH YIELD SYNTHESIS METHODS FOR PRODUCING ORGANIC SALTS OF STRONTIUM | Osteologix A/S (DK) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003200-A2 | HIGH YIELD SYNTHESIS METHODS FOR PRODUCING ORGANIC SALTS OF STRONTIUM | OSTEOLOGIX A/S (DK) | 2007-01-11 | — | — | WO | disclosed |